Aminophylline / Promethazine
Aminophylline/Promethazine is a combination medication that pairs a bronchodilator with an antihistamine. Aminophylline works to relax airway smooth muscles and improve breathing, while promethazine provides antihistamine effects along with antiemetic and sedative properties. This combination may be used for respiratory conditions where both airway relaxation and allergy-related symptoms or nausea need to be addressed.
A combined bronchodilator and antihistamine used for respiratory conditions with associated allergy symptoms or nausea.
Key facts at a glance
- RxNorm
- 1008464
- Generic
- Aminophylline / Promethazine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
May be used for respiratory conditions such as asthma or COPD exacerbations, particularly when accompanied by allergic symptoms or nausea. The combination addresses both bronchospasm and associated symptoms requiring antihistamine/antiemetic coverage.
Aminophylline (a theophylline derivative) relaxes bronchial smooth muscle by inhibiting phosphodiesterase and adenosine receptors, while promethazine blocks histamine H1 receptors and has CNS depressant effects. Together they provide both bronchodilation and relief from allergy-related symptoms.
Use with caution in patients with cardiovascular disease, seizures, or glaucoma. Promethazine can cause significant sedation and should not be used in children under 2 years old. Requires monitoring of theophylline levels for aminophylline dosing. May interact with other CNS depressants, anticoagulants, and various bronchodilators.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy