Amitriptyline / Chlordiazepoxide
Amitriptyline/Chlordiazepoxide is a combination medication that merges a tricyclic antidepressant with a benzodiazepine anxiolytic. It is prescribed primarily for the treatment of moderate to severe anxiety associated with depression, leveraging the rapid anti-anxiety effects of chlordiazepoxide alongside the mood-elevating properties of amitriptyline.
A combination antidepressant-anxiolytic used for anxiety with depressive symptoms.
Key facts at a glance
- RxNorm
- 974990
- Generic
- Amitriptyline / Chlordiazepoxide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for moderate to severe anxiety disorders with co-occurring depression, particularly when anxiety symptoms are prominent. May also be used for other conditions as determined by a healthcare provider.
Chlordiazepoxide enhances GABAergic transmission in the central nervous system, producing anxiolytic and sedative effects, while amitriptyline inhibits the reuptake of serotonin and norepinephrine to alleviate depressive symptoms.
Due to the benzodiazepine component, risk of dependence exists with prolonged use; discontinuation should be gradual under medical supervision. May cause significant drowsiness and impaired motor function; alcohol should be avoided. Not recommended for use in the elderly, those with narrow-angle glaucoma, or individuals recovering from substance abuse. Patients should be monitored for worsening depression or suicidal ideation, especially when initiating therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy