Amivantamab / Hyaluronidase
Amivantamab/hyaluronidase is a targeted cancer therapy combining a bispecific antibody with an enzyme that enables subcutaneous administration. It is specifically indicated for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations, after progression on or after platinum-based chemotherapy.
A targeted therapy for EGFR exon 20-mutated NSCLC given as a subcutaneous injection.
Key facts at a glance
- RxNorm
- 2729292
- Generic
- Amivantamab / Hyaluronidase
- Class
- multi-ingredient
- Brands
- Rybrevant Faspro
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, following progression on or after platinum-based chemotherapy. Testing for EGFR exon 20 mutations is required before initiating therapy.
Amivantamab is a bispecific antibody that simultaneously targets both EGFR and MET receptors on cancer cells, blocking their signaling pathways that drive tumor growth. The hyaluronidase component temporarily breaks down subcutaneous tissue, allowing for subcutaneous injection of the large antibody molecule.
Administered as a subcutaneous injection. Common side effects include infusion-related reactions, skin toxicity, paronychia, and musculoskeletal pain. Requires monitoring for interstitial lung disease and embryo-fetal toxicity. Must be administered by a healthcare professional.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy