Amlodipine / Hydrochlorothiazide / Valsartan
This medication combines three blood pressure-lowering agents to manage hypertension when single medications prove insufficient. It is prescribed for patients requiring multi-drug therapy to achieve adequate blood pressure control, typically when two medications have not been effective.
A triple-combination antihypertensive for patients whose blood pressure requires treatment with three different medications.
Key facts at a glance
- RxNorm
- 852897
- Generic
- Amlodipine / Hydrochlorothiazide / Valsartan
- Class
- multi-ingredient
- Brands
- Exforge HCT
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension in adults who are not adequately controlled on two antihypertensive agents, or as initial therapy for patients likely to need multiple drugs to achieve blood pressure goals.
Combines three mechanisms: amlodipine (calcium channel blocker) relaxes blood vessel walls; hydrochlorothiazide (thiazide diuretic) reduces fluid volume through increased urination; valsartan (ARB) blocks angiotensin II receptors to prevent vessel narrowing.
May cause dizziness, headache, or peripheral swelling. Avoid potassium supplements unless prescribed. Contraindicated in pregnancy. May interact with NSAIDs, lithium, and certain other medications. Regular monitoring of blood pressure, electrolytes, and kidney function is recommended.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy