Amorolfine
Amorolfine is a topical antifungal medication primarily used to treat fungal infections of the nails and skin. It belongs to the morpholine class of antifungals and is available as a nail lacquer or cream formulation for easy application to affected areas.
Amorolfine is a topical antifungal used to treat nail and skin fungal infections like onychomycosis and athlete's foot.
Key facts at a glance
- ATC
- D01AE16
- RxNorm
- 17804
- Generic
- Amorolfine
- Class
- atc-d01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- cream, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- Apply once weekly
- Maximum
- consult physician
- Frequency
- once weekly
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- Apply once weekly
- Maximum
- consult physician
- Frequency
- once weekly
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- Apply once weekly
- Maximum
- consult physician
- Frequency
- once weekly
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesterno adjustment needed
use only if clearly needed, topical application has minimal systemic absorption
standard prenatal care
Use with caution and monitor for adverse effects.
pregnancy
second trimesterno adjustment needed
use only if benefits outweigh minimal risks
standard prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesterno adjustment needed
continue as prescribed for nail fungal infection
standard prenatal care
Use with caution and monitor for adverse effects.
lactation
nursing mothersno adjustment needed
topical application unlikely to affect breast milk, avoid applying to breast area
none specific
pediatric_age
children under 12use with caution
limited data in children, only use if benefits clearly outweigh risks
monitor for skin irritation
Use with caution and monitor for adverse effects.
geriatric
elderly over 65no adjustment needed
suitable for elderly patients, monitor for skin sensitivity
check for local skin reactions
renal_impairment
mild to moderateno adjustment needed
no dosage adjustment required due to minimal systemic absorption
none specific
hepatic_impairment
mild to moderateno adjustment needed
no adjustment required due to topical route
none specific
Statistics and clinical data
Commonly prescribed since
First approved in Europe for topical treatment of onychomycosis
Drug class
ATC code D01AE14
Common uses
Primary therapeutic indication
Primary formulation
Topical lacquer for nail application
Amorolfine is indicated for the treatment of fungal nail infections (onychomycosis) caused by dermatophytes, yeasts, and molds. It may also be used for fungal skin infections such as tinea pedis (athlete's foot), tinea cruris, and tinea corporis when topical therapy is appropriate.
Amorolfine works by inhibiting the fungal enzymes delta14-reductase and delta7,8-isomerase, which are essential for synthesizing ergosterol, a critical component of the fungal cell membrane. By disrupting ergosterol production, the medication causes structural and functional damage to the fungal cell membrane, leading to inhibition of fungal growth and replication.
Amorolfine is for topical use only and should not be applied to eyes or mucous membranes. Patients should follow application instructions carefully, especially for nail infections where treatment duration may extend for several months. Adequate hygiene of affected areas and avoidance of occlusive dressings over treated areas is recommended. Medical consultation is advised if symptoms do not improve or worsen during treatment.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy