Amoxicillin / Floxacillin
Amoxicillin/Floxacillin is a combination antibiotic used to treat various bacterial infections. The combination pairs amoxicillin's broad-spectrum coverage with floxacillin's resistance to beta-lactamase enzymes, making it particularly effective against staphylococcal infections and other gram-positive bacteria. This medication is commonly prescribed for respiratory, skin, and soft tissue infections where coverage against resistant bacteria is needed.
A combination antibiotic providing broad-spectrum coverage including resistant staphylococci.
Key facts at a glance
- RxNorm
- 1008111
- Generic
- Amoxicillin / Floxacillin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of respiratory tract infections, skin and soft tissue infections, and other bacterial infections caused by susceptible organisms including penicillinase-producing Staphylococcus aureus and other gram-positive bacteria.
Both amoxicillin and floxacillin are beta-lactam antibiotics that inhibit bacterial cell wall synthesis. Floxacillin is resistant to beta-lactamase enzymes, providing protection against resistant bacteria and extending the spectrum of activity.
Should be taken on an empty stomach (1 hour before or 2 hours after meals). Patients with penicillin allergy should not use this medication. Common side effects include gastrointestinal disturbances, and prolonged use may result in fungal or bacterial superinfection. Complete the full course as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy