Ampicillin / Floxacillin
Ampicillin/Floxacillin is a combination antibiotic that combines two penicillin-class medications to provide broad-spectrum bacterial coverage. This combination is designed to treat infections caused by both penicillinase-producing bacteria and susceptible organisms, making it effective for various bacterial infections.
A broad-spectrum combination antibiotic used to treat bacterial infections by combining two penicillin-class drugs that work together to overcome bacterial resistance.
Key facts at a glance
- RxNorm
- 1007586
- Generic
- Ampicillin / Floxacillin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats various bacterial infections including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and infections caused by penicillinase-producing Staphylococcus aureus. Specific indications should be determined by a healthcare provider based on culture and sensitivity testing.
Both medications are beta-lactam antibiotics that inhibit bacterial cell wall synthesis. Ampicillin provides coverage for susceptible Gram-positive and some Gram-negative bacteria, while Floxacillin's penicillinase-resistant structure allows it to remain effective against bacteria that produce penicillin-destroying enzymes.
Patients with penicillin allergy should avoid this medication. Common side effects may include gastrointestinal symptoms, rash, and allergic reactions. Complete the full prescribed course even if symptoms improve. May interact with other medications including methotrexate and blood thinners. Effectiveness may be reduced by tetracyclines and erythromycin.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy