Amylase / Lipase / Protease
Amylase/Lipase/Protease is a combination of digestive enzymes that helps break down carbohydrates, fats, and proteins in the gastrointestinal tract. This medication is typically prescribed to individuals with pancreatic insufficiency or conditions that impair natural enzyme production, such as chronic pancreatitis, cystic fibrosis, or after certain pancreatic surgeries. The enzymes are taken with meals to assist in proper nutrient digestion and absorption.
Digestive enzyme supplement containing amylase, lipase, and protease used to help break down food components in people with insufficient natural enzyme production.
Key facts at a glance
- RxNorm
- 392491
- Generic
- Amylase / Lipase / Protease
- Class
- multi-ingredient
- Brands
- Zenpep, Viokace, Pertzye, Pancreaze, PanaKare, PancrePlus, Creon
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat pancreatic insufficiency, chronic pancreatitis, cystic fibrosis, pancreatic surgery or removal, gastro-jejunal feeding tube issues, and other conditions where the body cannot produce adequate digestive enzymes. It may also be used in cases of age-related enzyme decline.
The three enzymes work together to break down food components: Amylase breaks down carbohydrates and starches into simple sugars, Lipase breaks down fats into fatty acids and glycerol, and Protease breaks down proteins into amino acids. This allows for proper nutrient absorption in the small intestine.
Should be taken with meals and snacks as directed by a healthcare provider. Do not crush or chew enteric-coated tablets. Effectiveness depends on proper dosing relative to fat, protein, and carbohydrate content of meals. Report symptoms like severe stomach pain, nausea, or unusual bowel movements to your doctor. May interact with certain medications and supplements.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy