Andexanet Alfa
Andexanet Alfa is a specialized reversal agent designed to counteract the effects of direct oral anticoagulants that target factor Xa. It is administered in emergency situations when patients taking rivaroxaban or apixaban experience life-threatening or uncontrolled bleeding.
Andexanet alfa is a targeted antidote that reverses serious bleeding in patients taking factor Xa inhibitor anticoagulants.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- V03AB38
- RxNorm
- 2045114
- Generic
- Andexanet Alfa
- Class
- atc-v03
- Brands
- Andexxa
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Emergency reversal of life-threatening or uncontrolled bleeding in patients treated with direct factor Xa inhibitors, specifically rivaroxaban and apixaban.
This recombinant protein binds directly to factor Xa inhibitors (rivaroxaban, apixaban) in the bloodstream, sequestering them and neutralizing their anticoagulant effect to restore normal hemostasis.
Reserved for emergency use only; not indicated for routine reversal or for heparin-induced thrombocytopenia. May increase risk of thrombotic events. Administration requires close monitoring for recurrence of bleeding or clot formation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy