Anisotropine / Phenobarbital
Anisotropine/Phenobarbital is a combination medication pairing an anticholinergic antispasmodic with a barbiturate sedative. This older formulation was primarily used to treat gastrointestinal conditions involving spasms and cramping, particularly peptic ulcer disease and irritable bowel syndrome, where the antispasmodic helped relax intestinal smooth muscle while the sedative component promoted relaxation and reduced anxiety associated with these conditions.
An older combination antispasmodic and sedative medication used for gastrointestinal disorders involving muscle spasms and associated anxiety.
Key facts at a glance
- RxNorm
- 1007368
- Generic
- Anisotropine / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for gastrointestinal conditions with smooth muscle spasms, including peptic ulcer disease, irritable bowel syndrome, and other functional GI disorders. May also be used for bladder spasms.
Anisotropine is an anticholinergic that blocks acetylcholine receptors, reducing parasympathetic stimulation and relaxing smooth muscle in the GI tract. Phenobarbital is a barbiturate that enhances GABA activity, producing sedation and anxiolytic effects.
This is an older medication with limited use in modern practice due to the availability of safer alternatives. Barbiturates carry risks of dependence, tolerance, and dangerous drug interactions. Anticholinergic effects may cause dry mouth, constipation, urinary retention, and blurred vision. Not recommended for elderly patients or those with glaucoma, urinary obstruction, or myasthenia gravis.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy