Antazoline
Antazoline is a first-generation antihistamine medication primarily used in nasal spray formulations to relieve symptoms of allergic rhinitis. It is commonly combined with xylometazoline to address nasal congestion alongside other allergic symptoms. The medication provides relief from sneezing, itching, and runny nose associated with seasonal or perennial allergies.
Antazoline is an antihistamine nasal spray used to treat allergic rhinitis symptoms like sneezing, itching, and runny nose.
Key facts at a glance
- ATC
- R01AC04
- RxNorm
- 865
- Generic
- Antazoline
- Class
- atc-r01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteruse only if clearly needed
avoid unless benefits outweigh potential risks to fetus
regular prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse only if clearly needed
avoid close to delivery due to potential effects on newborn
regular prenatal care and fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingminimal adjustment needed
use with caution as small amounts may pass into breast milk
monitor infant for unusual drowsiness or irritability
Use with caution and monitor for adverse effects.
geriatric
elderlystandard dose
use with caution due to increased sensitivity to antihistamine effects
monitor for dry eyes, urinary retention, and CNS effects
Use with caution and monitor for adverse effects.
pediatric_age
children under 2not recommended
avoid use in infants and toddlers under 2 years
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children 2 to 12use under medical supervision
use only when prescribed by a physician
monitor for systemic effects
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderateno adjustment needed
no special dosage adjustment required due to minimal systemic absorption
standard monitoring
hepatic_impairment
mild to moderateno adjustment needed
no special dosage adjustment required due to minimal systemic absorption
standard monitoring
Statistics and clinical data
Drug class
Pharmacological classification as H1 receptor antagonist
Common uses
Therapeutic indications
Regulatory status
Current market availability
Historical prescribing period
Period of active use in clinical practice
Antazoline is indicated for the symptomatic relief of allergic rhinitis, including seasonal hay fever and perennial allergic rhinitis. It helps alleviate nasal symptoms such as sneezing, itching, rhinorrhea (runny nose), and nasal congestion when combined with decongestants.
Antazoline works as a competitive antagonist at H1 histamine receptors. By blocking histamine, it prevents the inflammatory and allergic responses that cause typical rhinitis symptoms. When combined with xylometazoline, it provides complementary relief through vasoconstriction of nasal blood vessels.
As a first-generation antihistamine, antazoline may cause drowsiness and should be used with caution when operating machinery or driving. It is typically intended for short-term use. Patients with glaucoma, urinary retention, or severe cardiovascular conditions should consult a healthcare provider before use. Not recommended for prolonged use without medical supervision.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy