Antazoline / Xylometazoline
Antazoline/Xylometazoline is a combination nasal spray medication that provides relief from nasal allergy symptoms. Antazoline, an antihistamine, helps reduce sneezing, itching, and runny nose by blocking histamine receptors, while xylometazoline, a decongestant, shrinks swollen nasal passages to relieve congestion. This combination is typically prescribed for allergic rhinitis and nasal congestion associated with colds or allergies.
A combination antihistamine and decongestant nasal spray for relieving allergy symptoms and nasal congestion.
Key facts at a glance
- RxNorm
- 687089
- Generic
- Antazoline / Xylometazoline
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of allergic rhinitis, nasal congestion, rhinorrhea, sneezing, and itching associated with upper respiratory allergies and the common cold.
Antazoline blocks H1 histamine receptors to reduce allergic responses, while xylometazoline constricts blood vessels in the nasal mucosa through alpha-adrenergic stimulation, reducing swelling and congestion.
For nasal use only; prolonged use of xylometazoline (beyond 3-5 days) may cause rebound congestion. Use with caution in patients with hypertension, heart disease, or glaucoma. May cause local irritation or dryness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy