Antipyrine / Caffeine / Quinine
This combination medication contains antipyrine (an analgesic), caffeine (a stimulant), and quinine (a muscle relaxant). It was historically used to treat tension headaches and migraines. Due to safety concerns with quinine and the availability of safer alternatives, this formulation is rarely prescribed today.
Historical headache/migraine treatment combining pain relief, stimulation, and muscle relaxation, now largely replaced by safer modern medications.
Key facts at a glance
- RxNorm
- 1007437
- Generic
- Antipyrine / Caffeine / Quinine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tension headaches and migraines. Note: This is an older formulation with limited modern use due to safety concerns associated with its ingredients.
Antipyrine provides analgesic and antipyretic effects; caffeine may enhance pain relief and cause vasoconstriction; quinine acts as a muscle relaxant.
Quinine can cause serious adverse effects including cardiac arrhythmias and cinchonism. This medication is not commonly prescribed today and has largely been replaced by safer alternatives such as acetaminophen with caffeine or triptans for migraines. Use only under medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy