Antipyrine / Hydrocortisone / Neomycin / Polymyxin B
This combination medication is used to treat ear infections, particularly otitis externa (swimmer's ear) and other conditions involving bacterial infection and inflammation of the outer ear canal. It contains two antibiotics (neomycin and polymyxin B) to fight bacteria, a corticosteroid (hydrocortisone) to reduce inflammation and swelling, and an analgesic (antipyrine) to relieve ear pain.
A combination ear drop medication that treats bacterial ear infections while reducing inflammation and pain.
Key facts at a glance
- RxNorm
- 689241
- Generic
- Antipyrine / Hydrocortisone / Neomycin / Polymyxin B
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute otitis externa (swimmer's ear), chronic otitis externa, and other infections of the external ear canal caused by susceptible bacteria. May also be used for inflammatory ear conditions requiring anti-infective therapy.
Neomycin and polymyxin B work together to kill a wide range of gram-negative and gram-positive bacteria by disrupting bacterial cell membranes. Hydrocortisone reduces inflammation, swelling, and itching in the ear canal, while antipyrine provides local analgesic and anti-inflammatory effects to relieve pain.
For otic use only (ears). Avoid contact with eyes. Should not be used if the eardrum is perforated. Neomycin may cause hearing loss or kidney damage with prolonged use. Discontinue if sensitization or allergic reaction occurs. Complete the full course of treatment as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy