Apazone
Apazone is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with rheumatic conditions. It belongs to the ATC M01 class of anti-inflammatory and antirheumatic medications.
Apazone is an NSAID used to reduce pain and inflammation in rheumatic conditions.
Key facts at a glance
- ATC
- M01AX04
- RxNorm
- 1029
- Generic
- Apazone
- Class
- atc-m01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular prenatal care
Use with caution and monitor for adverse effects.
pregnancy
second trimesteravoid if possible
use only if benefits outweigh potential risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid
contraindicated in third trimester due to risk of premature closure of ductus arteriosus
fetal ultrasound monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid or use lowest effective dose
small amounts may pass into breast milk, monitor infant for adverse effects
observe infant for GI upset, bleeding
Use with caution and monitor for adverse effects.
geriatric
elderlystart with lower dose, reduce maintenance dose
increased risk of GI bleeding, renal impairment, and cardiovascular events; use lowest effective dose for shortest duration
monitor renal function, GI symptoms, blood pressure
Use with caution and monitor for adverse effects.
pediatric_age
childrennot recommended
not recommended for use in children due to increased risk of adverse effects
n/a
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mild renal impairmentreduce dose, monitor closely
use with caution, may worsen renal function
monitor renal function tests regularly
Use with caution and monitor for adverse effects.
renal_impairment
severe renal impairmentavoid
contraindicated in patients with severe renal impairment due to risk of acute renal failure
renal function monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild hepatic impairmentreduce dose, monitor closely
use with caution as drug is metabolized in liver
monitor liver function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentavoid
contraindicated in severe hepatic impairment
liver function monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Regulatory status
Safety and regulatory information
Primarily used for rheumatoid arthritis and other inflammatory conditions involving pain and swelling of joints. May also be used for other acute inflammatory disorders.
Like other NSAIDs in the M01 class, it works by inhibiting cyclooxygenase (COX) enzymes, reducing the production of prostaglandins that cause inflammation, pain, and fever.
Common side effects include gastrointestinal disturbances. Use with caution in patients with a history of ulcers, kidney problems, or heart conditions. Avoid in late pregnancy. Not recommended for children.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy