Apraclonidine Hydrochloride
Apraclonidine Hydrochloride is an alpha-2 adrenergic agonist ophthalmic solution primarily used to reduce elevated intraocular pressure in patients with glaucoma or ocular hypertension. It is also commonly prescribed to prevent or control post-surgical intraocular pressure elevation following laser eye procedures.
An alpha-2 agonist eye drop that lowers eye pressure in glaucoma patients and after eye surgery.
Key facts at a glance
- RxNorm
- 91350
- Generic
- Apraclonidine Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension, and prevention of postoperative intraocular pressure spikes following laser procedures such as argon laser trabeculoplasty or iridotomy.
Acts as an alpha-2 adrenergic receptor agonist in the eye, reducing aqueous humor production and slightly increasing uveoscleral outflow, resulting in decreased intraocular pressure.
May cause drowsiness; patients should avoid driving until effects are known. Not recommended as first-line therapy due to potential for systemic absorption and rebound hypertension after discontinuation. Contraindicated in patients using MAO inhibitors. Common side effects include ocular discomfort, dryness, and hyperemia.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy