Fondaparinux
Arixtra (fondaparinux) is a synthetic anticoagulant medication used to prevent and treat blood clots. It works by selectively inhibiting Factor Xa, a key enzyme in the blood clotting cascade, through its binding to antithrombin III. This medication is primarily used in patients undergoing orthopedic surgeries or those with existing deep vein thrombosis and pulmonary embolism.
Arixtra is a blood thinner used to prevent and treat dangerous blood clots by inhibiting Factor Xa.
Key facts at a glance
- RxNorm
- 322155
- Generic
- Arixtra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of deep vein thrombosis (DVT) in patients undergoing orthopedic surgery such as hip fracture, hip replacement, or knee replacement surgery; treatment of acute DVT and pulmonary embolism when used with warfarin or alone in certain patients.
Arixtra is a synthetic pentasaccharide that binds to antithrombin III, enhancing its ability to inhibit Factor Xa. By selectively blocking Factor Xa, it prevents the conversion of prothrombin to thrombin, thereby reducing blood clot formation without directly affecting existing clots.
Administered by subcutaneous injection, typically once daily. Contraindicated in patients with severe kidney impairment, active bleeding, or bacterial endocarditis. Close monitoring for bleeding complications is essential. Not interchangeable with heparin or low molecular weight heparins. May increase risk of spinal/epidural hematoma in patients undergoing neuraxial anesthesia.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 2, 2026. · Read our editorial policy