Artemether / Lumefantrine
Artemether/Lumefantrine is a fixed-dose combination antimalarial medication used to treat acute, uncomplicated Plasmodium falciparum malaria and mixed infections. It combines an artemisinin derivative with a long-acting antimalarial agent for effective parasite clearance.
An antimalarial combination therapy used to treat uncomplicated malaria caused by Plasmodium falciparum.
Key facts at a glance
- RxNorm
- 282448
- Generic
- Artemether / Lumefantrine
- Class
- multi-ingredient
- Brands
- Coartem
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute, uncomplicated malaria caused by Plasmodium falciparum, including mixed infections. Not recommended for malaria prophylaxis or for severe/complicated malaria requiring parenteral therapy.
Artemether rapidly reduces parasite biomass with a short half-life, while lumefantrine (a aryl amino alcohol) eliminates remaining parasites with a longer duration of action. This combination provides both rapid symptom relief and sustained cure.
Should be taken with food or milky drink to enhance absorption. Complete the full course even if symptoms improve. Not recommended in patients with severe cardiac arrhythmias or known QT prolongation. Resistance has been reported in some regions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy