Aspirin / Butalbital / Caffeine
Aspirin/Butalbital/Caffeine is a combination medication used primarily for treating tension headaches and migraines. It combines an analgesic (aspirin), a barbiturate sedative (butalbital), and a stimulant (caffeine) to address both the pain and underlying tension associated with headaches.
A combination headache treatment containing aspirin, a sedative, and caffeine used for tension-type headaches.
Key facts at a glance
- RxNorm
- 282422
- Generic
- Aspirin / Butalbital / Caffeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension-type headaches and sometimes migraines characterized by head pain, muscle tension, and associated symptoms.
Aspirin provides analgesic and anti-inflammatory effects; butalbital acts as a sedative to reduce anxiety and tension; caffeine enhances pain relief and may help constrict dilated blood vessels.
Contains butalbital, a controlled substance with risk of dependence and withdrawal; generally recommended for short-term use only; avoid in patients with certain medical conditions; may cause drowsiness; use caution when operating machinery.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy