Aspirin / Butalbital / Caffeine / Phenacetin
This combination medication is used to treat tension-type headaches and certain types of pain. It combines a barbiturate sedative (butalbital), pain relievers (aspirin and phenacetin), and caffeine to address both the physical and vascular components of headache pain.
A combination analgesic-sedative medication for tension headaches that combines aspirin, butalbital, caffeine, and phenacetin.
Key facts at a glance
- RxNorm
- 689507
- Generic
- Aspirin / Butalbital / Caffeine / Phenacetin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension-type headaches and mild to moderate pain conditions where relaxation and pain relief are both needed.
Butalbital provides sedative and anxiolytic effects, aspirin and phenacetin work as analgesics to reduce pain signals, and caffeine may enhance pain relief by promoting vasoconstriction in cerebral blood vessels.
Contains a barbiturate and is considered habit-forming. Phenacetin has been associated with kidney toxicity with long-term use and is banned in many countries. Should not be used in patients with certain medical conditions; risk of overuse headaches with frequent use. Use only as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy