Aspirin / Caffeine / Cinnamedrine
Aspirin/Caffeine/Cinnamedrine is a multi-ingredient over-the-counter medication combining an NSAID pain reliever, a stimulant, and a decongestant. This combination targets multiple symptoms simultaneously, making it commonly used for headache, sinus pressure, and cold-related discomfort. The three active ingredients work together to reduce pain, increase alertness, and relieve nasal congestion.
A combination analgesic-decongestant used for headache, sinus pressure, and cold symptoms.
Key facts at a glance
- RxNorm
- 466424
- Generic
- Aspirin / Caffeine / Cinnamedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of headache, minor aches and pains, sinus pressure and congestion, and symptoms associated with colds or upper respiratory allergies. May also be used for migraine-associated symptoms in some formulations.
Aspirin provides analgesic and anti-inflammatory effects by inhibiting prostaglandin synthesis. Caffeine acts as a CNS stimulant and may enhance aspirin’s pain-relieving effects. Cinnamedrine, an alpha-adrenergic agonist, acts as a decongestant by constricting blood vessels in the nasal passages and sinuses, reducing swelling and congestion.
Avoid use in individuals allergic to aspirin or other NSAIDs. Should not be used in children or teenagers recovering from viral infections due to Reye’s syndrome risk. Consult a healthcare provider if pregnant, breastfeeding, or taking blood thinners. May cause drowsiness or interact with other medications. Not recommended for prolonged daily use without medical supervision.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy