Aspirin / Caffeine / Codeine
A combination analgesic medication that brings together the anti-inflammatory and pain-relieving effects of aspirin, the vasoconstrictor and stimulant properties of caffeine, and the opioid-based pain relief of codeine. This multi-ingredient formulation is typically prescribed for the management of moderate to moderately severe pain, such as tension headaches, dental procedures, and muscle aches.
A combination pain reliever using aspirin, caffeine, and codeine for moderate pain management.
Key facts at a glance
- RxNorm
- 689511
- Generic
- Aspirin / Caffeine / Codeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the relief of moderate to moderately severe pain conditions including tension headaches, migraines, dental pain, post-surgical pain, muscle aches, and menstrual cramps. The combination targets multiple pain pathways simultaneously.
Aspirin inhibits cyclooxygenase enzymes to reduce prostaglandin production and inflammation; caffeine enhances analgesic effectiveness by constricting cerebral blood vessels and increasing alertness; codeine binds to mu-opioid receptors in the central nervous system to alter pain perception.
Contains codeine, an opioid with potential for dependence and tolerance. Not recommended for children, adolescents recovering from surgery, or pregnant women near delivery. May cause drowsiness, constipation, or gastrointestinal irritation from aspirin. Avoid with alcohol and other CNS depressants. Should only be used as prescribed due to risks of respiratory depression with higher doses.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy