Aspirin / Caffeine / Dihydrocodeine
This medication combines three active ingredients: an opioid analgesic (dihydrocodeine), a nonsteroidal anti-inflammatory drug (aspirin), and a stimulant (caffeine). The combination is typically prescribed for managing moderate to severe pain when other pain relievers are insufficient. Caffeine is included to potentially enhance the analgesic effects and counteract drowsiness from the opioid component.
A combination pain medication containing an opioid, NSAID, and stimulant used for moderate to severe pain relief.
Key facts at a glance
- RxNorm
- 689512
- Generic
- Aspirin / Caffeine / Dihydrocodeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to relieve moderate to severe pain, such as pain from injuries, dental procedures, surgery, or other conditions requiring opioid-level analgesia when combination therapy is deemed appropriate by a healthcare provider.
Dihydrocodeine binds to opioid receptors in the brain and nervous system to reduce pain perception. Aspirin inhibits prostaglandin synthesis, reducing inflammation and pain. Caffeine may enhance aspirin absorption and potentiate analgesic effects while reducing opioid-induced drowsiness.
Contains an opioid component with risk of dependence, tolerance, and addiction. Should not be used in patients with aspirin allergy, bleeding disorders, or asthma. Avoid alcohol and other CNS depressants. May cause drowsiness, dizziness, or constipation. Use only as prescribed and do not exceed recommended duration.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy