Aspirin / Caffeine / Dihydrocodeine / Promethazine
This combination medication combines an opioid analgesic (dihydrocodeine), a nonsteroidal anti-inflammatory drug (aspirin), a stimulant (caffeine), and an antihistamine with sedative properties (promethazine). It is typically prescribed for moderate to severe pain, particularly when additional relief from nausea or anxiety is needed. The ingredients work together to provide pain relief through multiple mechanisms while promethazine helps with nausea and may promote sedation.
A combination pain medication containing an opioid, NSAID, stimulant, and sedative antihistamine used for moderate to severe pain with associated nausea.
Key facts at a glance
- RxNorm
- 689513
- Generic
- Aspirin / Caffeine / Dihydrocodeine / Promethazine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of moderate to severe pain, particularly when accompanied by nausea, anxiety, or when sedation is beneficial. The combination may be used for conditions such as post-operative pain, trauma, or severe headache where multi-modal pain control is desired.
Dihydrocodeine binds to opioid receptors in the brain to reduce pain perception; aspirin inhibits prostaglandin synthesis to reduce inflammation and pain; caffeine may enhance analgesic effects and counteract drowsiness; promethazine blocks histamine receptors and has antiemetic and sedative properties.
This medication contains an opioid and carries risks of dependence, tolerance, and respiratory depression. It should not be combined with alcohol, other CNS depressants, or MAO inhibitors. Aspirin component increases bleeding risk. Use is typically limited to short-term treatment due to addiction potential. Always follow prescribing physician's instructions carefully.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy