Aspirin / Caffeine / Hydrocodone
Aspirin/Caffeine/Hydrocodone is a combination analgesic medication used for the management of moderate to severe pain. It combines an NSAID (aspirin) for anti-inflammatory effects, a stimulant (caffeine) that may enhance pain relief, and an opioid (hydrocodone) for stronger analgesic action. This combination is typically prescribed when other pain medications are insufficient.
A triple-combination pain medication pairing an NSAID, stimulant, and opioid for moderate to severe pain relief.
Key facts at a glance
- RxNorm
- 689515
- Generic
- Aspirin / Caffeine / Hydrocodone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This combination medication is prescribed for the relief of moderate to moderately severe pain, such as that associated with injuries, dental procedures, or surgical recovery.
Hydrocodone binds to opioid receptors in the brain to reduce pain perception, while aspirin inhibits inflammatory processes and caffeine may amplify the analgesic effects of the other components.
This medication carries risks associated with opioid use, including dependence and side effects like drowsiness and constipation. Patients with aspirin allergy or bleeding disorders should avoid it. Due to its opioid component, it's typically reserved for cases where non-opioid alternatives prove inadequate.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy