Aspirin / Caffeine / Orphenadrine
This is a combination medication containing aspirin (a pain reliever and anti-inflammatory), caffeine (a stimulant that may enhance pain relief), and orphenadrine (a muscle relaxant). It is typically used to treat acute musculoskeletal conditions involving pain, tension, and muscle spasms.
A combination pain reliever and muscle relaxant used for acute musculoskeletal pain and tension.
Key facts at a glance
- RxNorm
- 466549
- Generic
- Aspirin / Caffeine / Orphenadrine
- Class
- multi-ingredient
- Brands
- Norgesic, Orphengesic
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for acute musculoskeletal pain conditions such as muscle strains, tension headaches, and conditions involving both pain and muscle tension or spasms.
Aspirin provides analgesic and anti-inflammatory effects, caffeine may enhance aspirin absorption and pain-relieving properties, and orphenadrine acts as a muscle relaxant to reduce muscle spasms.
Should be used short-term only. Not appropriate for individuals with aspirin allergy, stomach ulcers, bleeding disorders, or those taking blood thinners. Avoid caffeine close to bedtime. Use only as directed by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy