Aspirin / Caffeine / Propoxyphene
This multi-ingredient medication combines an NSAID (aspirin), a stimulant (caffeine), and an opioid analgesic (propoxyphene) for pain relief. The combination was historically used to treat mild to moderate pain such as headaches, dental pain, and muscle aches.
A discontinued analgesic combination of aspirin, caffeine, and an opioid used for pain relief.
Key facts at a glance
- RxNorm
- 689518
- Generic
- Aspirin / Caffeine / Propoxyphene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the relief of mild to moderate pain including headaches, dental pain, muscle aches, and menstrual cramps. Note: This product has been withdrawn from the US market due to safety concerns.
Aspirin provides anti-inflammatory and analgesic effects; caffeine acts as a CNS stimulant that may enhance pain relief; propoxyphene binds to opioid receptors to reduce pain perception.
This medication is no longer marketed in many countries including the US due to cardiac safety concerns with propoxyphene. It carried risks of dependence, respiratory depression, GI bleeding from aspirin, and cardiac arrhythmias. Patients should consult current pain management options with their healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy