Aspirin / Caffeine / Quinine
This multi-ingredient medication combines aspirin for pain and inflammation relief, caffeine as a stimulant to enhance analgesic effects and reduce drowsiness, and quinine for potential muscle cramp relief. It is primarily used for treating various pain conditions including headaches, muscle aches, and menstrual discomfort, with the quinine component historically included for addressing nocturnal leg cramps.
A combination analgesic medication containing aspirin, caffeine, and quinine used for pain relief with potential muscle relaxant properties.
Key facts at a glance
- RxNorm
- 817778
- Generic
- Aspirin / Caffeine / Quinine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain including headaches, muscle aches, menstrual cramps, and general discomfort. Historically used for tension headaches and nocturnal leg cramps due to the quinine component.
Aspirin provides analgesic and anti-inflammatory effects by inhibiting prostaglandin synthesis. Caffeine acts as a central nervous system stimulant that may enhance pain relief and counteract drowsiness. Quinine has muscle relaxant and antimalarial properties, though its exact role in pain relief formulations is less defined.
Aspirin carries risks of gastrointestinal bleeding and should be avoided in patients with bleeding disorders. Caffeine may cause anxiety, insomnia, or palpitations in sensitive individuals. Quinine has been associated with rare but serious cardiac effects and cinchonism (tinnitus, dizziness). This combination is less commonly prescribed today due to safety concerns with quinine and the availability of safer alternatives.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy