Aspirin / Caffeine / Salicylamide
This multi-ingredient medication combines two salicylates (aspirin and salicylamide) with caffeine for enhanced pain and fever relief. The caffeine component acts as a mild stimulant that may improve the effectiveness of the analgesics for treating headaches and general aches. It is typically used for mild to moderate pain, headaches, and fever in adults.
A combination analgesic containing aspirin and salicylamide with caffeine for enhanced pain and headache relief in adults.
Key facts at a glance
- RxNorm
- 689519
- Generic
- Aspirin / Caffeine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain including headaches, toothaches, muscle aches, and menstrual cramps. Also used for fever reduction and general discomfort from colds or minor arthritis pain.
Aspirin inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin production, decreasing pain and inflammation. Salicylamide provides additional analgesic effects through similar salicylate activity. Caffeine enhances the effectiveness of the other pain relievers and may help constrict dilated blood vessels associated with headaches.
Not for use in children or teenagers due to risk of Reye's syndrome. Should be avoided by those with aspirin allergies, bleeding disorders, or stomach ulcers. Caffeine content may cause insomnia, nervousness, or interact with other stimulants. Avoid alcohol as it may increase stomach irritation risk. Consult a healthcare provider before use if pregnant, breastfeeding, or taking blood thinners.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy