Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine
This combination medication provides relief from multiple cold and flu symptoms. Aspirin addresses pain and fever, chlorpheniramine helps with sneezing and runny nose, dextromethorphan suppresses coughing, and phenylephrine reduces nasal congestion. This medication is typically used by adults seeking relief from upper respiratory symptoms associated with colds or allergies.
A multi-symptom cold and flu medication combining pain/fever relief, antihistamine, cough suppressant, and decongestant.
Key facts at a glance
- RxNorm
- 1111420
- Generic
- Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold and flu symptoms including headache, fever, minor aches and pains, nasal congestion, sinus congestion, runny nose, sneezing, and cough.
Aspirin inhibits prostaglandin production to reduce fever and pain. Chlorpheniramine blocks histamine receptors to relieve allergic symptoms. Dextromethorphan suppresses the cough reflex in the brain. Phenylephrine constricts blood vessels in nasal passages to reduce swelling and congestion.
Not for use in children or teenagers recovering from viral illness due to Reye's syndrome risk with aspirin. Avoid if taking MAO inhibitors, have stomach ulcers, bleeding disorders, or uncontrolled hypertension. May cause drowsiness; avoid alcohol and operating machinery. Consult healthcare provider if symptoms persist beyond 7 days or are accompanied by fever lasting more than 3 days.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy