Aspirin / Chlorpheniramine / Dextromethorphan / Phenylpropanolamine
This multi-ingredient medication combines four active ingredients to provide relief from multiple cold and flu symptoms. Aspirin addresses pain and fever, chlorpheniramine helps with allergic reactions and sneezing, dextromethorphan suppresses coughing, and phenylpropanolamine acts as a decongestant to reduce nasal swelling. It is typically used by adults seeking relief from respiratory infections, allergies, or sinus congestion.
A combination cold and allergy medication that relieves pain, fever, congestion, coughing, and sneezing.
Key facts at a glance
- RxNorm
- 1007613
- Generic
- Aspirin / Chlorpheniramine / Dextromethorphan / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of symptoms associated with the common cold, influenza, allergic rhinitis, sinus congestion, and related respiratory conditions including headache, fever, body aches, nasal congestion, runny nose, sneezing, and cough.
Aspirin inhibits cyclooxygenase enzymes to reduce pain, fever, and inflammation. Chlorpheniramine blocks histamine H1 receptors to prevent allergic symptoms. Dextromethorphan suppresses the cough reflex in the brain. Phenylpropanolamine stimulates alpha-adrenergic receptors to constrict blood vessels and reduce nasal congestion.
Not recommended for children or teenagers due to the aspirin component and risk of Reye's syndrome. Should not be used by individuals taking MAO inhibitors, those with glaucoma, urinary retention, or severe hypertension. May cause drowsiness; avoid operating machinery. Consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy