Aspirin / Chlorpheniramine / Phenylephrine
This multi-ingredient medication combines an antihistamine, pain reliever, and decongestant to address multiple cold and allergy symptoms simultaneously. It is typically used for temporary relief of nasal congestion, sneezing, runny nose, headache, body aches, and fever associated with the common cold or seasonal allergies. This medication is generally intended for adults and should not be used in children due to the aspirin content.
A combination cold/allergy medication that relieves congestion, sneezing, runny nose, and pain/fever symptoms.
Key facts at a glance
- RxNorm
- 818496
- Generic
- Aspirin / Chlorpheniramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of nasal and sinus congestion, sneezing, runny nose, itchy/watery eyes, headache, minor body aches, and fever associated with the common cold, flu, or seasonal allergies.
Chlorpheniramine blocks histamine receptors to reduce allergic symptoms; phenylephrine constricts blood vessels in nasal passages to reduce swelling and congestion; aspirin inhibits prostaglandin production to relieve pain and reduce fever.
Not recommended for children due to Reye's syndrome risk associated with aspirin. Avoid use if taking blood thinners, with MAO inhibitors, or if you have stomach ulcers, glaucoma, or heart conditions. May cause drowsiness; avoid alcohol and operating machinery. Consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy