Aspirin / Citric Acid / Sodium Bicarbonate
This effervescent combination medication pairs aspirin with buffering agents (sodium bicarbonate and citric acid) to provide relief from pain, fever, and inflammation. The effervescent formulation dissolves in water and may be easier on the stomach than regular aspirin tablets. It is commonly used for headaches, minor aches, and muscle pain.
An effervescent buffered aspirin formulation for pain and fever relief that may be gentler on the stomach.
Key facts at a glance
- RxNorm
- 689524
- Generic
- Aspirin / Citric Acid / Sodium Bicarbonate
- Class
- multi-ingredient
- Brands
- Bromo Seltzer Antacid Pain Reliever, Alka-Seltzer
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor aches and pains associated with headaches, toothaches, menstrual cramps, muscle aches, and fever due to common cold or flu. Not typically used for daily cardiovascular prevention when in this effervescent combination form.
Aspirin inhibits cyclooxygenase (COX) enzymes, reducing the production of prostaglandins that cause pain, inflammation, and fever. The sodium bicarbonate and citric acid create an effervescent solution that may enhance absorption and help neutralize stomach acid, potentially reducing gastrointestinal irritation.
Should not be given to children or teenagers with fever or flu symptoms due to the risk of Reye's syndrome. People with aspirin allergies, bleeding disorders, or stomach ulcers should avoid this medication. Avoid alcohol as it may increase the risk of stomach bleeding. Consult a healthcare provider before use if taking blood thinners or other NSAIDs.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy