Aspirin / Codeine
Aspirin/Codeine is a combination medication that pairs an anti-inflammatory agent with an opioid analgesic to manage moderate to severe pain. This medication is typically prescribed when over-the-counter pain relievers alone prove insufficient. The combination addresses both inflammatory and pain signaling pathways for more comprehensive pain relief.
A combination pain medication using aspirin and codeine for moderate to severe pain management.
Key facts at a glance
- RxNorm
- 135095
- Generic
- Aspirin / Codeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat moderate to severe pain, particularly when associated with inflammation. It may be prescribed for conditions such as post-operative pain, dental procedures, injuries, or other painful conditions requiring stronger analgesia than single-agent OTC medications can provide.
Aspirin works by inhibiting cyclooxygenase (COX) enzymes, reducing prostaglandin production that causes inflammation, pain, and fever. Codeine is an opioid that binds to mu-opioid receptors in the brain and nervous system, altering the perception of pain and providing additional analgesic effects. Together, these agents target pain through both peripheral anti-inflammatory action and central nervous system opioid pathways.
This medication carries risks associated with both components, including gastrointestinal irritation and bleeding from aspirin, and potential dependence, respiratory depression, and constipation from codeine. It should not be used in children recovering from viral infections due to Reye's syndrome risk. Patients should avoid alcohol and inform their doctor of any respiratory conditions, ulcers, bleeding disorders, or history of substance use before taking this medication. Long-term use requires medical supervision due to addiction potential with the codeine component.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy