Aspirin / Cyclizine
Aspirin/Cyclizine is a combination medication that pairs the pain-relieving and anti-inflammatory effects of aspirin with the anti-nausea properties of cyclizine, an antihistamine. This combination is particularly useful for treating painful conditions where nausea or vomiting accompanies the primary symptom, such as migraines or tension headaches.
A combination analgesic and antiemetic medication used to treat pain associated with nausea.
Key facts at a glance
- RxNorm
- 819817
- Generic
- Aspirin / Cyclizine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain, headaches, and migraines, especially when accompanied by nausea or vomiting. May also be used for post-operative pain and dysmenorrhea where antiemetic coverage is beneficial.
Aspirin works by inhibiting cyclooxygenase (COX) enzymes, reducing prostaglandin production that causes pain and inflammation. Cyclizine is an H1 antihistamine that blocks histamine receptors in the vomiting center of the brain, preventing nausea and vomiting.
Avoid in patients with aspirin allergy, active peptic ulcer disease, or bleeding disorders. Should not be used in children due to risk of Reye's syndrome. May cause drowsiness; avoid alcohol and operating machinery. Consult a doctor if symptoms persist beyond 3 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy