Aspirin / Dextromethorphan / Doxylamine / Phenylephrine
This combination medication contains four active ingredients to address multiple cold and flu symptoms simultaneously. Aspirin provides pain relief and fever reduction, dextromethorphan suppresses coughing, doxylamine acts as an antihistamine to relieve allergy symptoms and may aid sleep, while phenylephrine reduces nasal congestion. This medication is typically used by adults seeking relief from upper respiratory symptoms associated with colds, allergies, or mild influenza.
A multi-symptom cold and flu medication combining pain/fever relief, cough suppression, allergy relief, and nasal decongestion.
Key facts at a glance
- RxNorm
- 1053120
- Generic
- Aspirin / Dextromethorphan / Doxylamine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or allergies including headache, minor aches and pains, fever, cough, runny nose, sneezing, itchy nose or throat, and nasal congestion
Aspirin inhibits prostaglandin production to reduce pain, fever, and inflammation. Dextromethorphan suppresses the cough reflex in the brain. Doxylamine blocks histamine receptors to reduce allergic symptoms and may cause drowsiness. Phenylephrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
Not recommended for children or teenagers due to Reye's syndrome risk with aspirin. Should not be combined with alcohol or other sedatives. Patients with certain conditions (heart disease, high blood pressure, thyroid disorders, glaucoma, urinary problems) should consult a healthcare provider before use. May cause drowsiness; avoid driving or operating machinery.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy