Aspirin / Diphenhydramine
Aspirin/Diphenhydramine is a combination medication that pairs the pain-relieving and anti-inflammatory effects of aspirin with the antihistamine properties of diphenhydramine. This combination is typically used for treating allergy symptoms such as sneezing, runny nose, and itchy eyes, while also providing relief from minor aches and pains. The diphenhydramine component may also help with sleep when taken at bedtime.
A combination medication for allergy relief with added pain relief and potential sleep-inducing effects.
Key facts at a glance
- RxNorm
- 669119
- Generic
- Aspirin / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of allergy symptoms including sneezing, watery eyes, and runny nose; minor aches and pains associated with allergies or cold symptoms; nighttime use when drowsiness may be beneficial.
Aspirin inhibits cyclooxygenase (COX) enzymes to reduce inflammation, pain, and fever. Diphenhydramine blocks histamine H1 receptors to reduce allergic symptoms and causes drowsiness by crossing the blood-brain barrier.
May cause drowsiness; avoid operating machinery or driving until you know how it affects you. Should not be used in children or teenagers recovering from viral infections due to Reye's syndrome risk. Consult a healthcare provider if you have stomach problems, glaucoma, or urinary issues before use. Avoid alcohol while taking this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy