Aspirin / Hydrocodone
Aspirin/Hydrocodone is a prescription combination medication that pairs an opioid pain reliever with a nonsteroidal anti-inflammatory drug (NSAID). This combination is typically prescribed for managing moderate to severe pain that requires both opioid-level analgesia and anti-inflammatory effects, such as pain from injuries, dental procedures, or post-surgical recovery.
A prescription opioid-NSAID combination used for moderate to severe pain relief.
Key facts at a glance
- RxNorm
- 214253
- Generic
- Aspirin / Hydrocodone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prescribed for moderate to severe acute pain requiring opioid analgesia, such as pain following surgery, dental extractions, or serious injuries. May also be used when pain relief requiring both opioid and anti-inflammatory action is needed.
Hydrocodone binds to opioid receptors in the central nervous system to alter pain perception, while aspirin inhibits cyclooxygenase (COX) enzymes to reduce inflammation, fever, and pain at the site of injury.
This medication carries significant risks including dependence, addiction, and potentially fatal overdose. It should not be used by anyone with aspirin allergy, active peptic ulcer disease, or bleeding disorders. Combining opioids with other CNS depressants increases serious breathing risks. Use only as prescribed and never share with others.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy