Aspirin / Meprobamate
This combination medication pairs aspirin, a nonsteroidal anti-inflammatory drug (NSAID), with meprobamate, a tranquilizer and muscle relaxant. The aspirin component provides pain relief and reduces inflammation, while meprobamate addresses anxiety and muscle tension that may accompany painful conditions. This combination was historically used for tension-related headaches, musculoskeletal pain, and other conditions where both pain and anxiety or muscle spasm were present.
A combination analgesic-anxiolytic medication used for pain relief with associated anxiety or muscle tension.
Key facts at a glance
- RxNorm
- 214254
- Generic
- Aspirin / Meprobamate
- Class
- multi-ingredient
- Brands
- Equagesic
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension headaches, musculoskeletal pain, and other painful conditions associated with anxiety, tension, or muscle spasms. May also be used for mild to moderate pain where calming effects are beneficial.
Aspirin inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis to decrease pain, inflammation, and fever. Meprobamate acts on GABA-A receptors in the central nervous system, producing anxiolytic and muscle relaxant effects that help relieve tension and anxiety.
Meprobamate carries risks of dependence, tolerance, and withdrawal with prolonged use. The combination may cause significant drowsiness and should be used with caution when operating machinery or consuming alcohol. Aspirin component increases bleeding risk and may cause gastrointestinal irritation or ulcers. This medication has largely fallen out of common use due to safety concerns with meprobamate and the availability of safer alternatives. Should not be used in patients with bleeding disorders, pregnancy, or those taking blood thinners.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy