Aspirin / Methylprednisolone
Aspirin/Methylprednisolone is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with a corticosteroid. This multi-ingredient formulation provides both rapid anti-inflammatory and analgesic effects from aspirin alongside the potent anti-inflammatory and immunosuppressive properties of the corticosteroid methylprednisolone. The combination may be used in specific inflammatory or allergic conditions where both mechanisms are therapeutically beneficial.
A combination anti-inflammatory medication pairing an NSAID with a corticosteroid for conditions requiring dual anti-inflammatory action.
Key facts at a glance
- RxNorm
- 1008080
- Generic
- Aspirin / Methylprednisolone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This combination may be prescribed for inflammatory conditions, allergic reactions, or autoimmune disorders requiring both rapid and sustained anti-inflammatory response. Specific indications should be determined by a healthcare provider based on individual patient needs.
Aspirin inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, providing analgesic and anti-inflammatory effects. Methylprednisolone works by binding to glucocorticoid receptors, suppressing inflammatory gene expression and modulating immune responses. Together they provide complementary anti-inflammatory mechanisms.
Both components carry risks including gastrointestinal irritation and bleeding (aspirin), and metabolic changes, immunosuppression, and adrenal suppression (corticosteroids). This combination requires medical supervision and is not appropriate for self-treatment. Patients should inform their doctor of all medications and health conditions before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy