Aspirin / Omeprazole
Aspirin/Omeprazole is a combination medication that pairs the antiplatelet effects of aspirin with the stomach acid-reducing properties of omeprazole. This combination is designed for patients who require aspirin's cardiovascular protective effects but need protection against aspirin-related gastrointestinal complications. The medication is primarily used for long-term management in appropriate patients.
A combination drug pairing aspirin with a stomach protectant for patients needing cardiovascular protection who are at risk for GI side effects.
Key facts at a glance
- RxNorm
- 1811630
- Generic
- Aspirin / Omeprazole
- Class
- multi-ingredient
- Brands
- Yosprala
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of cardiovascular events (such as heart attack and stroke) in patients requiring low-dose aspirin therapy who have a risk of gastrointestinal ulcers or bleeding. Often prescribed for patients with established cardiovascular disease or those with a history of aspirin-related GI intolerance.
Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing thromboxane production and decreasing platelet aggregation to prevent blood clot formation. Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by blocking the H+/K+ ATPase enzyme in stomach parietal cells, reducing the risk of gastric ulcers associated with aspirin use.
Do not discontinue aspirin abruptly without medical consultation, as this may increase cardiovascular risk. Inform your healthcare provider of all medications to avoid interactions (particularly other anticoagulants, NSAIDs, or clopidogrel). Common side effects may include headache, abdominal pain, and nausea. Seek emergency care for signs of bleeding such as unusual bruising, black stools, or blood in urine.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy