Aspirin / Oxycodone
Aspirin/oxycodone is a prescription combination analgesic that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an opioid to manage moderate to severe pain requiring opioid-level relief. It is typically prescribed when non-opioid pain relievers alone provide insufficient relief. The two medications work through complementary mechanisms to address pain from multiple pathways.
A prescription opioid-NSAID combination for managing moderate to severe pain when other analgesics are inadequate.
Key facts at a glance
- RxNorm
- 214256
- Generic
- Aspirin / Oxycodone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of moderate to severe pain requiring opioid-level analgesia where treatment with an opioid is clinically appropriate, and where non-opioid alternatives have proven insufficient.
Aspirin inhibits cyclooxygenase (COX) enzymes, reducing inflammation and pain at the site of injury. Oxycodone is an opioid agonist that binds to mu-opioid receptors in the central nervous system, altering the perception of and response to pain. The combination provides analgesia through both peripheral (NSAID) and central (opioid) mechanisms.
Contains an opioid with significant risks including dependence, tolerance, respiratory depression, and misuse. Associated with gastrointestinal bleeding from aspirin and increased bleeding risk. Contraindicated with bleeding disorders, active ulcers, or perioperative pain management for coronary artery bypass grafting. May cause drowsiness; alcohol and CNS depressants potentiate these effects. Not appropriate for mild or intermittent pain.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy