Aspirin / Pentazocine
This combination medication pairs pentazocine, a mixed opioid agonist-antagonist analgesic, with aspirin, a non-steroidal anti-inflammatory drug (NSAID). The two agents work through different mechanisms to provide pain relief for moderate to severe pain conditions. This type of combination may be prescribed when single-agent therapy is insufficient for pain management.
Aspirin/Pentazocine is a combination analgesic used for moderate to severe pain, leveraging both opioid and NSAID mechanisms of action.
Key facts at a glance
- RxNorm
- 214257
- Generic
- Aspirin / Pentazocine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe pain when combination analgesia is clinically appropriate. May be used for various pain conditions requiring stronger analgesia than single-agent over-the-counter options provide.
Pentazocine acts as a partial agonist at opioid kappa receptors and antagonist at mu receptors, modulating pain perception. Aspirin inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and providing anti-inflammatory and analgesic effects.
Due to the opioid component, use carries risks of dependence, sedation, and respiratory depression. Aspirin carries risks of GI bleeding and should be avoided in certain populations. Combination use requires careful medical supervision and is typically reserved for situations where benefits outweigh risks. Patients should follow prescribed dosing exactly and report any adverse effects to their healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy