Aspirin / Phenobarbital
Aspirin/Phenobarbital is a combination medication that pairs an NSAID (aspirin) with a barbiturate (phenobarbital) to address both pain and associated anxiety or tension. This combination is typically prescribed for conditions like tension headaches, muscle pain, or migraines where anxiety accompanies the painful symptoms. The dual-action approach allows the aspirin to reduce inflammation and pain while phenobarbital provides calming effects.
Combination analgesic and sedative used for pain conditions accompanied by anxiety or tension.
Key facts at a glance
- RxNorm
- 812525
- Generic
- Aspirin / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension-type headaches, muscle pain with anxiety component, and migraines. May be used for other painful conditions where relaxation is desired alongside pain relief.
Aspirin inhibits cyclooxygenase enzymes to reduce inflammation, pain, and fever. Phenobarbital enhances GABA neurotransmitter activity in the brain, producing sedative and anxiolytic effects that help relax muscles and reduce stress-related pain components.
Avoid in children/teens due to Reye's syndrome risk with aspirin. Phenobarbital can cause drowsiness, dependency, and withdrawal; avoid alcohol and operating machinery. Not suitable for long-term use. Consult healthcare provider about drug interactions, especially with blood thinners, other sedatives, or seizure medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy