Aspirin / Phenylephrine
This combination medication pairs Aspirin with the nasal decongestant Phenylephrine to provide relief from multiple cold and flu symptoms simultaneously. It addresses both the pain, fever, and inflammation commonly experienced during respiratory illnesses, along with nasal congestion. This medication is typically used by adults seeking relief from sinus pressure, headache, and stuffy nose associated with colds or allergies.
Aspirin/Phenylephrine is a combination cold medication that relieves pain, fever, and nasal congestion.
Key facts at a glance
- RxNorm
- 814664
- Generic
- Aspirin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or allergies including nasal congestion, sinus congestion, headache, minor aches and pains, and fever.
Aspirin inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing pain, fever, and inflammation. Phenylephrine is an alpha-adrenergic agonist that constricts blood vessels in the nasal passages, reducing swelling and congestion.
Not recommended for children or teenagers due to Reye's syndrome risk. Should be avoided by those with bleeding disorders, recent surgery, or who are taking blood thinners. Do not use with other aspirin or NSAID products. Consult a healthcare provider if you have heart disease, high blood pressure, thyroid disorders, or are pregnant or breastfeeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy