Aspirin / Phenylpropanolamine
Aspirin/Phenylpropanolamine is a combination medication that pairs an analgesic (aspirin) with a decongestant (phenylpropanolamine) to address multiple cold and flu symptoms simultaneously. This product was previously available over-the-counter for temporary relief of nasal congestion, sinus pressure, headache, and minor aches. Due to safety concerns associated with phenylpropanolamine, formulations containing this ingredient have been withdrawn from the market in many countries.
A cold/flu medication combining pain relief with decongestion that is no longer widely available due to safety concerns.
Key facts at a glance
- RxNorm
- 817405
- Generic
- Aspirin / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication was used for temporary relief of nasal congestion, sinus pressure, headache, body aches, and fever associated with the common cold, flu, or sinusitis.
Aspirin works by inhibiting cyclooxygenase (COX) enzymes to reduce pain, inflammation, and fever. Phenylpropanolamine is a sympathomimetic agent that constricts blood vessels in the nasal passages, reducing swelling and congestion.
Phenylpropanolamine has been withdrawn from many markets due to associated risks of stroke, particularly in women. This medication should not be used by those with cardiovascular disease, hypertension, thyroid disorders, or who are taking MAO inhibitors. Patients should consult their healthcare provider for current alternative treatments for cold and flu symptoms.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy