Aspirin / Propoxyphene
Aspirin/Propoxyphene was a combination analgesic medication that paired the anti-inflammatory and pain-relieving properties of aspirin with the opioid-like effects of propoxyphene. It was prescribed for the management of moderate to severe pain when other treatments were insufficient. However, this combination is no longer widely available due to safety concerns with the propoxyphene component.
A discontinued pain medication combining aspirin with an opioid-like agent, now largely obsolete due to safety concerns.
Key facts at a glance
- RxNorm
- 689541
- Generic
- Aspirin / Propoxyphene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication was used for the relief of moderate to moderately severe pain, such as pain following surgery, dental procedures, or injury. The combination was intended for patients requiring stronger analgesia than aspirin alone could provide.
Aspirin works by inhibiting cyclooxygenase (COX) enzymes, reducing inflammation, pain, and fever. Propoxyphene is a weak opioid analgesic that acts on opioid receptors in the central nervous system to alter pain perception. Together, they provided pain relief through complementary mechanisms.
Propoxyphene was withdrawn from the US market in 2010 and from the European Union in 2009 due to serious cardiac safety concerns, including the risk of potentially fatal heart rhythm abnormalities. This combination product is no longer available in most countries. Patients were transitioned to safer pain management alternatives. Both components carry individual risks including gastrointestinal effects from aspirin and dependence potential from opioid-related agents.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy