Astemizole / Clorazepate
Astemizole/Clorazepate is a combination medication that pairs an antihistamine with a benzodiazepine. This multi-ingredient product addresses both allergic symptoms and anxiety-related conditions simultaneously.
A multi-ingredient medication combining an antihistamine with an anxiolytic for conditions involving both allergies and anxiety.
Key facts at a glance
- RxNorm
- 1008348
- Generic
- Astemizole / Clorazepate
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
May be used for managing allergic conditions such as rhinitis and urticaria alongside anxiety disorders or situational anxiety. The benzodiazepine component may also provide sedative effects for procedural sedation or alcohol withdrawal management.
Astemizole works as a histamine H1 receptor antagonist to reduce allergic symptoms. Clorazepate enhances the effect of GABA neurotransmitters in the brain, producing anxiolytic, sedative, and muscle relaxant effects.
Astemizole was withdrawn from many markets due to cardiac risks including QT prolongation. This combination requires careful monitoring for sedation, respiratory depression, and drug interactions. Use is typically reserved for specific clinical scenarios where both components are warranted.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy