Astemizole / Dexamethasone
Astemizole/Dexamethasone is a combination medication that was used for managing allergic conditions by targeting both the inflammatory response and histamine release. Astemizole, a second-generation antihistamine, was combined with dexamethasone, a corticosteroid, to provide relief from allergic symptoms. This combination is no longer available in most markets due to safety concerns.
A discontinued antihistamine-corticosteroid combination previously used for allergic conditions, withdrawn due to cardiac safety risks.
Key facts at a glance
- RxNorm
- 1007105
- Generic
- Astemizole / Dexamethasone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This combination was used for various allergic conditions including allergic rhinitis, urticaria, and other hypersensitivity reactions where both anti-inflammatory and antihistamine effects were desired.
Astemizole blocks H1 histamine receptors to reduce allergic symptoms like itching and sneezing, while dexamethasone suppresses the inflammatory response and immune system activity through glucocorticoid receptor binding.
Astemizole has been withdrawn from markets worldwide due to serious cardiac arrhythmias (QT prolongation). This combination is not currently available. Patients should consult their healthcare provider about current FDA-approved alternatives for allergy management.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy