Atezolizumab / Hyaluronidase
Atezolizumab/hyaluronidase is a combination immunotherapy medication used to treat various cancers, including non-small cell lung cancer, small cell lung cancer, hepatocellular carcinoma, and melanoma. The hyaluronidase component allows the medication to be administered as a subcutaneous injection under the skin rather than through intravenous infusion, making treatment more convenient for patients.
An immunotherapy drug that helps the immune system fight cancer cells, delivered via subcutaneous injection.
Key facts at a glance
- RxNorm
- 2693887
- Generic
- Atezolizumab / Hyaluronidase
- Class
- multi-ingredient
- Brands
- Tecentriq Hybreza
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat adults with various cancers including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma (HCC), melanoma, and alveolar soft part sarcoma. It may be used alone or in combination with other cancer treatments depending on the specific cancer type and stage.
Atezolizumab is a monoclonal antibody that blocks the PD-L1 protein on cancer cells, which normally helps them evade the immune system. By inhibiting PD-L1, the drug allows the body's immune cells (T cells) to recognize and attack cancer cells more effectively. The hyaluronidase component temporarily breaks down hyaluronic acid in the subcutaneous tissue, allowing the medication to be absorbed properly when injected under the skin.
This medication is administered by subcutaneous injection, typically over several minutes, which is significantly faster than traditional IV infusion. As an immunotherapy, it can cause immune-related side effects affecting various organs including the lungs, liver, colon, and endocrine glands. Treatment should be supervised by oncologists experienced in immunotherapy, with regular monitoring for side effects and treatment response.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy